Tachycardia: Medication and pacemaker interactions

Medicines for tachycardia that may interact with other medicines and with pacemakers and ICDs

Medicine

Important medicine interactions

Effect on pacemakers and ICDs

Amiodarone
  • Increases the effect of digoxin and warfarin
At high doses, may increase energy requirements on ICDs
Disopyramide
  • More potential for side effects when given with phenobarbital, phenytoin, or rifampin
 
Flecainide
  • Increases the effect of digoxin
 
Ibutilide Unknown
Lidocaine
  • More potential for side effects when given with propranolol, metoprolol, or cimetidine
 
Mexiletine
  • Increases the effect of theophylline
  • Less effective when given with phenobarbital, phenytoin, or rifampin
Not predictable
Procainamide
  • More potential for side effects when given with cimetidine, alcohol, or amiodarone
 
Propafenone
  • Increases the effect of digoxin, theophylline, and warfarin
  • Less effective when given with phenobarbital, phenytoin, or rifampin
  • More potential for side effects when given with cimetidine
 
Quinidine
  • Increases the effect of digoxin and warfarin
  • More potential for side effects when given with heparin, verapamil, or cimetidine
  • Less effective when given with phenobarbital, phenytoin, or rifampin
 
Sotalol
  • Increases the effect of other beta-blockers
May decrease energy requirements on ICDs

Last Updated: September 17, 2008

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