Benzodiazepines for restless legs syndrome

Examples

Generic Name Brand Name
alprazolam Xanax
clonazepam Klonopin
diazepam Valium
lorazepam Ativan
temazepam Restoril

How It Works

Benzodiazepines are sedative medicines. They affect chemicals in the nervous system and brain to reduce communication between nerve cells. This process improves sleep, relieves anxiety, and relaxes muscles for some people.

Why It Is Used

These drugs generally are used to treat anxiety, nervousness, muscular spasms, and seizures. Benzodiazepines may be used alone, usually for people who only have sleep problems or only have periodic limb movements. Low doses of benzodiazepines may also be used alone for the first attempts to relieve mild symptoms of restless legs syndrome. Benzodiazepines may be used with other drugs, such as dopamine, opioid, or anticonvulsant medicine, that have failed to improve symptoms when used alone. They are especially helpful in improving sleeplessness that has not been helped by other drugs.

How Well It Works

These medicines often help improve sleep quality and may reduce leg movements.

Side Effects

Side effects may include daytime sleepiness or confusion and dependency on the drug that may include difficult withdrawal. Sleep apnea may develop or become worse while taking benzodiazepines.

Many doctors are especially concerned about elderly patients taking these drugs. The sedative components of benzodiazepines increase the risk of falling, which may result in a serious injury in an older person.

The U.S. Food and Drug Administration (FDA) has issued a warning about clonazepam (Klonopin) and the risk of suicide and suicidal thoughts. The FDA does not recommend that people stop using this medicine. Instead, people who take clonazepam should be watched closely for warning signs of suicide. People who take clonazepam and who are worried about this side effect should talk to a doctor.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

These drugs may be combined with other treatments, such as levodopa or dopamine agonists or anticonvulsants such as gabapentin.

More study is needed to discover the full range of side effects. Benzodiazepines have not yet been reviewed by the U.S. Food and Drug Administration specifically for treatment of restless legs syndrome.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Last Updated: March 13, 2009

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