Hemophilia inheritance pattern

Picture of the inheritance pattern of hemophilia

Source: Hillman RS, et al. (2005). Hemophilia and other intrinsic pathway defects. In RS Hillman et al., eds., Hematology in Clinical Practice, 4th ed., chap. 32, pp. 368–379. New York: McGraw-Hill.

  • If the father has hemophilia and the mother is a carrier, sons will have a 50% chance of having hemophilia. Daughters will have a 50% chance of having hemophilia and a 50% chance of being a carrier. It is very rare for both parents to have these defective genes.
  • If the father does not have hemophilia and the mother is a carrier, sons will have a 50% chance of having hemophilia. Daughters will have a 50% chance of being carriers.
  • If the father has hemophilia and the mother has normal blood, all sons will be normal and all daughters will be carriers.

Last Updated: August 13, 2009

Author: Robin Parks, MS

Medical Review: E. Gregory Thompson, MD - Internal Medicine & Brian Leber, MDCM, FRCPC - Hematology

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